Correlation between dental fluorosis incidence and osteosarcoma incidence amongst provinces of Kenya and Association between fluoridation and osteosarcoma in Malaysia
نویسنده
چکیده
The Fluoride Action Network (FAN) submission “Revisiting the FluorideOsteosarcoma connection in the context of Elise Bassin’s findings: Part II” to the National Research Council (NRC) contained a postscript about an osteosarcoma epidemiology study in Kenya. This work by Bovill et. al. (1985) was never considered by the NRC in 1993, perhaps because the study was not specifically looking for a connection between osteosarcoma and fluoride. Yet our preliminary examination suggested it might provide important supporting evidence for an association. We are continuing research on this evidence.
منابع مشابه
Childhood Facial Osteosracoma: a Case Report
Osteosarcoma (OS) is the eighth common cancer of childhood and its incidence is 4 cases in one million in children younger than 14. Facial OS incidence is estimated between 8 and 10% of OS cases. The main etiology of OS is unknown, but various predisposing factors are proposed such as radiation, radiotherapy, some benign bone diseases like Paget’s disease or fibrous dysplasia. There is a 5-year...
متن کاملAPPENDIX 4. Kenya study, full, with introduction [Neurath 2005b]
The attached study was discussed in the NRC 2006 review, but was criticized because the osteosarcoma rates of Kenyan provinces were not age-‐adjusted. However, Kenyan provinces had large populations and it is unlikely there were large differences in ag distribution between provinces. Furthermore, the differences in osteosarcoma rates between provinces were as large as 400%. It is unlikely age ...
متن کاملExpression of Survivin in the Formalin-Fixed, Paraffin-embedded Specimens of Human Osteosarcoma May Be Used as a Diagnostic Marker
Osteosarcoma is the most frequent malignant bone tumor with a peak incidence in the second and third decades of life. Diagnosis of patients with osteosarcoma is limited to clinico-pathological parameters whereas molecular markers of tumor initiation and promotion have not yet been identified. We aimed to study the expression of the anti-apoptotic survivin gene in osteosarcoma specimens. A total...
متن کاملIs fluoride a risk factor for bone cancer? Small area analysis of osteosarcoma and Ewing sarcoma diagnosed among 0–49-year-olds in Great Britain, 1980–2005
BACKGROUND Artificial fluoridation of drinking water to improve dental health has long been a topic of controversy. Opponents of this public health measure have cited the possibility of bone cancer induction. The study objective was to examine whether increased risk of primary bone cancer was associated with living in areas with higher concentrations of fluoride in drinking water. METHODS Cas...
متن کامل